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产品中心Product Center
甲基化扩增子测序

甲基化扩增子测序


DNA甲基化是最早发现的表观遗传学修饰途径之一。大量研究表明,DNA甲基化能引起染色质结构、DNA构象、DNA稳定性及DNA与蛋白质相互作用方式的改变,从而控制基因表达。DNA甲基化通常抑制基因表达,去甲基化则诱导了基因重新活化和表达。通过对感兴趣的特定基因序列区域设计甲基化特异性PCR扩增引物,采用Bisulfite亚硫酸盐处理结合高通量测序的甲基化检测技术,运行生物信息分析方法对靶区域甲基化情况进行定量分析,研究基因甲基化与疾病的相关性。



  •        样本类型:新鲜组织或者血浆
  •        技术方法:(多重)BSP捕获 + NGS测序
  •        检测内容:目标基因组合(panel)甲基化水平



检测流程:



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